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. 2003 Sep 15;198(6):889–901. doi: 10.1084/jem.20030171

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Removal of CD4⁺CD25⁺ T cells before HSV infection enhances the expression of activation markers on virus-specific CD8⁺ T cells. Expression of activation markers on T cells gated on with double positive CD8⁺Vβ10⁺ cells in spleen of CD25-depleted and nondepleted mice were examined. Splenocytes from both groups were collected on day 14 post HSV infection and stained with anti–mouse CD8α and anti–mouse Vβ10 mAb in combination with an antibody against on activation marker (anti-CD44, CD62L, CD69, CD25, CCR5) and the appropriate isotype control using three color FACS^® analysis. Histograms are representative of four individual mice from one such experiment, and values reflect the percentage of cells expressing the respective marker.