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. 2003 Sep 15;198(6):889–901. doi: 10.1084/jem.20030171

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Copyright © 2003, The Rockefeller University Press

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Figure 8. — Adoptive transfer of HSV-specific memory CD8⁺ T cells generated in the absence of T_reg results in enhanced viral clearance than those generated in the presence of CD25⁺ regulatory T cells. Splenic MACS purified CD8⁺ T cells isolated from depleted and nondepleted animals 90 d p.i. were adoptively transferred into CD25-depleted naive B6 mice. 24 h posttransfer, mice were challenged in the hind FPs with 5 × 10⁶ pfu of HSV-1 KOS. The level of infectious HSV in the FP was observed from day 2 to 5 postchallenge. *P < 0.05. A higher virus load was always observed in CD25-depleted, HSV-infected group without any adoptive transfer compared with the groups with adoptive transfer (data not depicted).