Figure 4.

IFN-γ production by cross-reactive gastric T cell clones. Cytokine production was assessed in response to H. pylori lysate, H⁺,K⁺-ATPase, the H⁺,K⁺-ATPase epitope and the cross-reactive H. pylori epitope that induced T cell clone proliferation. For each clone, controls included medium alone, a couple of H⁺,K⁺-ATPase peptides flanking the stimulatory epitope and the series of candidate H. pylori epitopes that failed to induce T cell clone proliferation. Numbers in parentheses indicate the location of cross-reactive epitopes within the indicated H. pylori proteins. Results represent mean values ± SD of 4 representative out of 10 T cell clones tested.