Figure 1.

Macrophage emigration is regulated. A total of 12.5 × 10⁶ fluorescent green–labeled resident and red-labeled inflammatory macrophages were instilled into the peritoneal cavity of mice in the absence of peritonitis (noninflamed peritoneum) or mice with resolving peritonitis (inflamed peritoneum). (A) The number of resident (black bars) and inflammatory (gray bars) macrophages recovered from the peritoneal cavity after 3 d is shown. † significantly greater resident than inflammatory macrophage recovery (P < 0.05, n = 8/group). *, significantly greater recovery from noninflamed than inflamed peritoneum (P < 0.05). (B) Fluorescent-labeled macrophages in draining parathymic lymph nodes from the same mice. *, significantly more inflammatory than resident macrophages (P < 0.05, n = 8/group).