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. 2002 Dec 2;196(11):1483–1495. doi: 10.1084/jem.20001871

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — Concentration of secreted IgG1 (and IgE), IgG3, IgG2a, and IgG2b in 3-, 4- and 5-d cultures of stimulated 3H9sdVκ8sd scid and 3H9sdVκ8 scid/+ spleen cells. Spleen cells from individual 3H9sdVκ8sd scid and 3H9sdVκ8 scid/+ control mice were stimulated separately with LPS/IL4, LPS/TGFβ, and LPS alone, and then cell culture supernatants were tested for concentrations of secreted IgG1/IgE, IgG2b/IgA, and IgG2a/IgG3, respectively. The points (diamonds for 3H9sdVκ8sd scid and squares for 3H9sdVκ8 scid/+ controls) represent the concentrations of a given isotype in individual cell cultures (each culture corresponding to an individual mouse). Points on the abscissa correspond to ≤1 ng/ml. Culture conditions and starting cell concentrations were as described in Fig. 6 B.