Figure 1.

Effect of wortmannin (WM) on taurocholate-induced bile acid secretion in isolated perfused rat liver. Bile was collected at 3-min intervals in rats receiving taurocholate (100 μM at 30 ml/min for 39 min), which contained ³H taurocholate (1 × 10⁷ cpm/ml). Wortmannin (100 nM) was added to the perfusate for the last 9 min. Results are from one representative experiment, which was reproduced six times. Each point is a mean value obtained from triplicate samples.