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Effect of wortmannin and LY294002 on ATP-dependent transport of taurocholate and DNP-GS in canalicular membrane vesicles. (A) Time course of taurocholate transport with or without wortmannin (50nM). ○, −ATP; ●, +ATP; □, −ATP, +wortmannin; ■, +ATP, +wortmannin. (B) Time course of DNP-GS transport with or without wortmannin (50nM). ○, −ATP; ●, +ATP; □, −ATP, +wortmannin; ■, +ATP, +wortmannin.
