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Representative images of adenomas in small and large intestine of Apcmin/+ mice. Adenomas in small intestine (top) and colon (bottom) of Apcmin/+ mice with IRS-1+/+, IRS-1+/−, and IRS-1−/− genotypes are shown. Photographs were taken at ×12 under a dissecting scope with white-light optics underneath the specimen. Note the decrease in adenomas in IRS-1-deficient mice.
