Figure 3.

Effects of single and Dbl-HET mutations on DIO in male B6 mice. BW (A) and FFM (B) of male WT, Mc4r-HET, Lep-HET, and Dbl-HET mice maintained on a LFD from weaning until 17 wk and then switched to a HFD until 28 wk of age. Growth curve analysis of FM (C) and adiposity (percent body fat) (D) during exposure to the HFD. E, Endpoint data of adiposity expressed relative to WT mice. F, FM gained (g/wk) during high-fat feeding. Groups labeled “a” are statistically different from groups labeled “b” (P < 0.05); groups that share “a” are not significantly different from each other. *, P < 0.01 Mc4r-HET compared with WT, †, P < 0.05 compared with Lep-HET.