Table 1.
Fasting blood glucose, and serum insulin and leptin values for male WT, Mc4r-HET, Lep-HET, and Dbl-HET mice maintained on a LFD for 28 wk or a HFD from 17–28-wk of age
| Males | Glucose (mg/dl) | Insulin (ng/ml) | Leptin (ng/ml) |
|---|---|---|---|
| LFD | |||
| WT | 91 ± 7a | 0.2 ± 0.1 | 1.4 ± 0.6 |
| Mc4r-HET | 137 ± 13b | 1.1 ± 0.4 | 4.6 ± 2.1 |
| Lep-HET | 92 ± 3a | 0.5 ± 0.3 | 0.6 ± 0.1 |
| Dbl-HET | 124 ± 5b | 0.8 ± 0.4 | 3.5 ± 2.5 |
| HFD | |||
| WT | 127 ± 6a,a | 1.2 ± 0.4a | 17.1 ± 6.4a,a |
| Mc4r-HET | 189 ± 13b,a | 4.0 ± 0.6b,a | 44.4 ± 8.2b,a |
| Lep-HET | 142 ± 9a,a | 2.0 ± 0.5a | 6.2 ± 1.9a |
| Dbl-HET | 143 ± 12a | 3.2 ± 0.9a | 10.2 ± 2.6a |
Data were analyzed using two-way ANOVA, with genotype and diet as source of variation. Within diet, groups labeled ″a″ are statistically different from groups labeled ″b″ (P < 0.05); groups that share ″a″ are not significantly different from each other.
a
, Significant effect of diet within genotype (P < 0.01).