Table 2.
Fasting blood glucose, and serum insulin and leptin values for female WT, Mc4r-HET, Lep-HET, and Dbl-HET maintained on a LFD for 28 wk or switched to a HFD from 17–28 wk of age
| Females | Glucose (mg/dl) | Insulin (ng/ml) | Leptin (ng/ml) |
|---|---|---|---|
| LFD | |||
| WT | 86 ± 4 | 0.2 ± 0.1 | 0.7 ± 0.4 |
| Mc4r-HET | 97 ± 6 | 0.1 ± 0.0 | 3.0 ± 1.0 |
| Lep-HET | 100 ± 5 | 0.6 ± 0.3 | 0.8 ± 0.2 |
| Dbl-HET | 92 ± 5 | 1.3 ± 1.0 | 2.0 ± 0.8 |
| HFD | |||
| WT | 83 ± 5a | 1.0 ± 0.4 | 1.8 ± 0.4a,c |
| Mc4r-HET | 130 ± 5b,a | 1.3 ± 0.5 | 25.5 ± 5.1b,a |
| Lep-HET | 90 ± 7a | 0.7 ± 0.3 | 1.2 ± 0.3a |
| Dbl-HET | 132 ± 13b,a | 0.8 ± 0.3 | 19.2 ± 6.7b,c,a |
Data were analyzed using two-way ANOVA, with genotype and diet as source of variation. Groups labeled ″a″ are statistically different from groups labeled ″b″ (P < 0.01); groups that share ″a″ are not significantly different from each other.
a
, Significant effect of diet within genotype (P < 0.01).