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BMD and bone strength are increased in mice lacking the DCR. Femoral, spinal, and total-body BMD of 1- (A), 2- (B), or 5-month-old (C) male or female wild-type (WT) and DCR−/− mice. The same cohort of animals was used for each time point. D, Load-bearing properties of the sixth lumbar vertebra (maximum load and stress) from 6-month-old male WT and DCR−/− mice. Values are mean of 10–16 mice/group ± sd. KO, Knockout. *, P < 0.05, **, P < 0.01 vs. WT.
