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. 2007 Oct 11;149(1):146–153. doi: 10.1210/en.2007-0734

Figure 6.

Figure 6

DCR deletion reduces bone remodeling. Vertebral sections (L1–4) from 5-month-old female wild-type (WT) and DCR−/− mice were used to determine the following histomorphometric measurements: bone area over total tissue area (BA/TA) (A), trabecular width (Tb.Wi) (B), trabecular separation (Tb.Sp) (C), trabecular number (Tb.N) (D), osteoblast perimeter (Ob.pm/B.pm) (E), osteoclast perimeter (Oc.pm/B.pm) (F), bone formation rate per bone perimeter (BFR/B.pm) (G), activation frequency (Ac.F) (H), and cortical width (Ct.Wi) (K). Longitudinal undecalcified vertebral sections of WT (I) and DCR−/− (J) mice (unstained slides viewed without coverslips at ×25). Urinary DPD. (L), plasma osteocalcin (M), calcium (N), and PTH (O) levels. Values represent the mean of 12–18 mice/group ± sd. KO, Knockout. *, P < 0.05 vs. WT.

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