Figure 1.

Presence of 15-HPGD Hypomorphic Alleles Results in Decreased 15-HPGD mRNA Gene Expression

A, Wild-type (WT) Hpgd^+/+ and hypomorphic Hpgd^H/H alleles; B, Northern blot analysis of 15-HPGD mRNA in the adult lung, liver, and dpc 15.5 placenta, with cyclophilin mRNA detection provided as loading control; C, quantification of differences in 15-HPGD mRNA abundance in the adult lung, liver, and dpc 15.5 placenta normalized to wild-type values. Values are mean ± sem. ***, P < 0.001; *, P < 0.05; n = 3.