Figure 3.

Presence of 15-HPGD Hypomorphic Alleles Results in Decreased 15-HPGD Activity

The 15-HPGD hypomorphic alleles decrease 15-HPGD activity in adult lung and liver (A), dpc 11.5 fetal membranes (B), dpc 11.5 and 17.5 uterus (C), and dpc 11.5 and 17.5 placenta (D) compared with wild-type mice. 15-HPGD activity significantly decreases after dpc 17.5 in wild-type mice compared with dpc 11.5 in wild-type mice in fetal membranes (B), uterus (C), and placenta (D). Values are mean ± sem. ***, P < 0.001; **, P < 0.01; *, P < 0.05; n = 3–4. Measurements at dpc 18.25 do not differ between genotypes, and only wild-type samples are measured at dpc 19.0.