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Presence of 15-HPGD Hypomorphic Alleles Leads to Increased Concentrations of PGF2α
15-HPGD hypomorphic pregnancies have increased concentrations of PGF2α in the placenta (A), uterus (B), and ovary (C) on dpc 17.5 and dpc 18.25 (uterus only) relative to control mice. HpgdH/H ovarian PGF2α concentration is significantly increased at dpc 17.5 in comparison with dpc 15.5. Values are mean ± sem. ***, P < 0.001; **, P < 0.01; *, P < 0.05; n = 4–5.
