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. Author manuscript; available in PMC: 2008 Dec 19.

Published in final edited form as: Neuroscience. 2007 Oct 5;150(4):807–817. doi: 10.1016/j.neuroscience.2007.09.060

A, Thermal latencies (in s) to noxious heat were recorded every 15 min following intrathecal administration of deltorphin II (2.5 μg) to control littermates (Litt.; ), pro-enkephalin-KO (pENK-KO; ○), β-endorphin-KO (β-END-KO; □), and pro-dynorphin-KO (pDYN-KO; △) mice. B, Comparative latencies to paw withdrawal (in s) in control littermates, pENK-, β-END-, and pDYN-KO mice before (0 min) and 15 min after intrathecal injection of deltorphin II (2.5 μg). Number in parenthesis indicates the number of animals in each group. #, p < 0.0001 when ipsilateral 0 min are compared with their respective ipsilateral preCFA; two-tailed unpaired t-test.

Inline graphic — A, Thermal latencies (in s) to noxious heat were recorded every 15 min following intrathecal administration of deltorphin II (2.5 μg) to control littermates (Litt.; ), pro-enkephalin-KO (pENK-KO; ○), β-endorphin-KO (β-END-KO; □), and pro-dynorphin-KO (pDYN-KO; △) mice. B, Comparative latencies to paw withdrawal (in s) in control littermates, pENK-, β-END-, and pDYN-KO mice before (0 min) and 15 min after intrathecal injection of deltorphin II (2.5 μg). Number in parenthesis indicates the number of animals in each group. #, p < 0.0001 when ipsilateral 0 min are compared with their respective ipsilateral preCFA; two-tailed unpaired t-test.