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. Author manuscript; available in PMC: 2008 Dec 19.

Published in final edited form as: Neuroscience. 2007 Oct 5;150(4):807–817. doi: 10.1016/j.neuroscience.2007.09.060

Rotarod performances were evaluated in C57BL/6 mice following intrathecal injection of deltorphin II. A, Dose-dependent induction of motor uncoordination/ataxia-like behavior induced by deltorphin II (0–2.5 μg). ***, p < 0.001 when compared to saline-injected group (○), two-way ANOVA followed by Bonferroni’s multiple comparison test. B, Blockade of deltorphin II’s effect on motor functions with the DOR-selective antagonist naltrindole (NTI; 10 mg/kg) injected subcutaneously 15 min before administration of deltorphin II (2.5 μg; ▲). Control group ( ) received an equal volume of saline subcutaneously 15 min prior to deltorphin II. Mean performance before deltorphin (or before saline/NTI) injection represents the mean performance of all mice before treatment. **, p < 0.01 when compared to saline-pretreated group, two-way ANOVA followed by Bonferroni’s multiple comparison test. Number in parenthesis indicates the number of animals in each group.

Inline graphic — Rotarod performances were evaluated in C57BL/6 mice following intrathecal injection of deltorphin II. A, Dose-dependent induction of motor uncoordination/ataxia-like behavior induced by deltorphin II (0–2.5 μg). ***, p < 0.001 when compared to saline-injected group (○), two-way ANOVA followed by Bonferroni’s multiple comparison test. B, Blockade of deltorphin II’s effect on motor functions with the DOR-selective antagonist naltrindole (NTI; 10 mg/kg) injected subcutaneously 15 min before administration of deltorphin II (2.5 μg; ▲). Control group ( ) received an equal volume of saline subcutaneously 15 min prior to deltorphin II. Mean performance before deltorphin (or before saline/NTI) injection represents the mean performance of all mice before treatment. **, p < 0.01 when compared to saline-pretreated group, two-way ANOVA followed by Bonferroni’s multiple comparison test. Number in parenthesis indicates the number of animals in each group.