Figure 5.

Conservation of DNA binding domains in MutS, MSH6 and MSH7 proteins. Sequence alignment showing mismatch recognition domain (A) and clamp domains (B) derived from an alignment performed with full sequences. Tubes and strands indicate α-helices and β-strands, respectively. Black dots indicate residues that contact the DNA through hydrogen bonds. Locations of aligned sequences are indicated in the structure of E.coli MutS in Figure 6.