Figure 6.

DNA binding domains in MutS. Crystal structure of E.coli MutS dimer in complex with DNA substrate. In the monomer that contacts the mismatch directly, the mismatch binding domain and clamp domain are indicated in black, DNA in dark gray, and remaining part of protein in light gray. Numbers refer to start (431) and end (537) of aligned clamp domain sequences in Figure 5B. The open star indicates the position of the insertion found in the MSH6 proteins.