Table 3.
Genes deregulated in both human and animal stroke microarrays
| Human | Rat | Human | Rat | |||||
| Gene name | GenBank | SwissProt | GenBank | SwissProt | Max/min | Days | Max/min | Time |
| c-jun proto-oncogene | J04111 | P05412 | X17163 | P17325 | 4.4-fold | 9 – 20 | 3.5-fold | 1 h – 24 h |
| Matrix metalloproteinase 11 | X57766 | P24347 | U46034 | P97568 | 3.2-fold | 2 – 20 | 2.6-fold | 3 days |
| Calcium/calmodulin-dependent kinase (CAMK1) | L41816 | Q14012 | L24907 | Q63450 | 17.2-fold | 2 – 20 | 0.05-fold | 21 days |
| L26288 | Q63084 | |||||||
| LIM domain kinase 1 | D26309 | P53667 | D31873 | P53669 | 3.6-fold | 2 – 20 | 2.4-fold | 3 days |
| 0.4-fold | 21 days | |||||||
| T-Lymphocyte maturation-associated protein | M15800 | P21145 | U31367 | Q64349 | 1.7-fold | 2 – 6 | 0.2-fold | 21 days |
| Retinoic Acid Receptor beta | M84820 | P28702 | M81766 | P49743 | 2.0-fold | 2 – 6 | 0.1-fold | 21 days |
| S54072 | P28703 | |||||||
| Tyrosine Phosphatase 1B | M31724 | P18031 | M33962 | P20417 | 3.4-fold | 2 – 6 | 0.2-fold | 21 days |
| Adenosine A1 Receptor | S56143 | P30542 | M64299 | P25099 | 2.6-fold | 2 – 6 | 5.2-fold | 4 hrs |
| Growth arrest & DNA damage-inducible 153 | S40706 | P35638 | U30186 | Q62804 | 2.4-fold | 2 – 6 | 2.1-fold | 3 days |
| S62138 | ||||||||
| Glutamate Decarboxylase 67 | M81883 | Q99259 | M34445 | P18088 | 5.6-fold | 2 – 6 | 2.5-fold | 21 days |
| Glutamate Decarboxylase 65 | M81882 | Q99259 | M72422 | Q05683 | 22.7-fold | 2 – 20 | 2.2-fold | 3 days |
| Neurotrophin 3 | M37763 | P20783 | M34643 | P18280 | 5.1-fold | 2 – 37 | 2.2-fold | 12 hrs |
| Inhibitor of DNA binding 2 | M97796 | Q02363 | D10863 | P41137 | 5.6-fold | 2 – 20 | 0.4-fold | 21 days |
| Neuropeptide Y | K01911 | P01303 | M20373 | P07808 | 8.8-fold | 2 – 20 | 0.04-fold | 21 days |
| Glia Maturation Factor beta | M86492 | P17774 | Z11558 | Q63228 | 7.6-fold | 2 – 6 | 0.04-fold | 21 days |
| High Mobility Group Protein 1 | M23619 | P17096 | M64986 | P27109 | 4.3-fold | 2 – 37 | 3-fold | 4 h – 3 d |
| P27428 | 0.3-fold | 21 days | ||||||
| Early Growth Response Protein 1 | X52541 | P18146 | M18416 | P08154 | 4.4-fold | 2 – 20 | 3.9-fold | 1 h – 12 h |
| M62829 | J04154 | 0.2-fold | 21 days | |||||
| TAT-Binding Protein 1 | M34079 | P17980 | U77918 | P97638 | 3.8-fold | 2 – 20 | 0.4-fold | 21 days |
| Glutathione S-Transferase 1 | J03746 | P10620 | J03752 | P08011 | 17.5-fold | 2 – 20 | 10.8-fold | 24 h – 21 d |
| Fibroblast Growth Factor Receptor 1 | M63887 | Q02063 | D12498 | Q04589 | 10.1-fold | 2 – 20 | 4-fold | 4 h – 24 h |
| M63888 | Q02065 | |||||||
| M63889 | ||||||||
| Interleukin 10 | M57627 | P22301 | L02926 | P29456 | 2.4-fold | 2 – 20 26 – 37 | 6.4-fold | 21 days |
| Q63263 | 0.2-fold | |||||||
| Heat Shock Protein 27 | X54079 | P04792 | M86389 | P42930 | 0.6-fold | 2 – 20 | 15.2-fold | 4 h – 24 h |
| Heat Shock Protein 70 | M11717 | P08107 | Z27118 | Q63718 | 0.6-fold | 2 – 6 | 9.4-fold | 1 h – 24 h |
| P19790 | ||||||||
| Thioredoxin Peroxidase 1 | L19185 | P32119 | U06099 | P35704 | 4.9-fold | 2 – 20 | 3.9-fold | 21 days |
| X82321 | P31945 | |||||||
| Platelet-Derived Growth Factor A | X06374 | P04085 | L06894 | P28576 | 1.6-fold | 2 – 6 | 0.5-fold | 21 days |
| Matrix Metalloproteinase 14 | X83535 | Q92678 | X83537 | Q10739 | 6.9-fold | 2 – 6 | 3.3-fold | 24 h – 3 d |
| Kinase receptor TYRO3 Sky proto-oncogene | D17517 | Q06418 | D37880 | P55146 | 3.1-fold | 9 – 20 | 4.0-fold | 24 h – 3 d |
| 0.4-fold | 21 days | |||||||
| CSF-1-Receptor | X03663 | P07333 | X61479 | Q00495 | 89.2-fold | 9 – 20 | 2.8-fold | 3 days |
| Insulin-like Growth Factor Binding Protein 2 | M35410 | P18065 | J04486 | P12843 | 79.7-fold | 9 – 20 | 2.1-fold | 3 days |
| Mitogen activated kinase 1/2 | M84489 | P28482 | M64300 | P27703 | 48.6-fold | 9 – 20 | 0.3-fold | 21 days |
| Aquaporin 4 | U34846 | P55087 | U14007 | P47863 | 18-fold | 9 – 20 | 3.2-fold | 3 days |
| erbB2 proto-oncogene Neu proto-oncogene | M95667 | P04626 | X03362 | P06494 | 11.2-fold | 9 – 20 | 2.7-fold | 12 hrs |
| M11730 | Q14256 | |||||||
| L-type calcium channel β3 | U07139 | P54284 | M88751 | P54287 | 10.3-fold | 9 – 20 | 8.6-fold | 21 days |
| Ras-related protein RAB3A | M28210 | P20336 | X06889 | P05713 | 13.9-fold | 9 – 20 | 0.3-fold | 21 days |
| CAMK-II beta | U50358 | Q13554 | M16112 | P08413 | 1.8-fold | 9 – 20 | 0.3-fold | 21 days |
| Growth Factor Receptor-Bound 2 | L29511 | Q63057 | D49846 | Q63057 | 19.9-fold | 9 – 20 | 2.7-fold | 3 days |
| M96995 | Q14450 | Q14450 | ||||||
| Signal Transducer & Activator of Transcription 3 | L29277 | P40763 | X91810 | P52631 | 0.4-fold | 9 – 20 | 6.6-fold | 4 h – 3 d |
| 0.05-fold | 21 days | |||||||
| Neuronatin | U25033 | Q16517 | U08290 | Q62649 | 11.1-fold | 9 – 20 | 0.4-fold | 21 days |
| Q62663 | ||||||||
| Glutathione S-Transferase P | X08058 | P09211 | X02904 | P04906 | 3.1-fold | 9 – 20 | 0.1-fold | 1 hr |
| Glucocorticoid-regulated serine/threonine kinase GSK | AJ000512 | O00141 | L01624 | Q06226 | 0.6-fold | 26 – 37 | 2.4-fold | 3 days |
| 0.05-fold | 21 days | |||||||
| Glucose Transporter 1 | K03195 | P11166 | M13979 | P11167 | 0.6-fold | 26 – 37 | 11.6-fold | 4 h – 21 d |