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. 2007 Oct 25;7:70. doi: 10.1186/1472-6807-7-70

Figure 5.

Figure 5

Comparison of the nucleotide binding pockets and loop conformations. Stereo surface representation of the A. thaliana MTR kinase ADP-MTR complex and B. subtilis MTR kinase AMPPCP-MTR complex are shown in panel (a) and (c), respectively with the G- and W-loop coloured in green and the ligands shown as purple sticks. Stereo cartoon representations of the four functionally important loops, the G-loop, the W-loop, the Mg-binding DXE-motif, and the HGD catalytic loop, found in the A. thaliana and B. subtilis enzymes are shown in (b) and (d), respectively. Substrates and important residues discussed in the text are shown in stick presentation with the same colour scheme as in Figure 4b. Residues labelled with an asterisk indicate that disordered side chains are observed in at least one subunit of all known structures of the B. subtilis enzyme. This figure was prepared using PyMOL [51].