Table 4.

Multivariate analysis of the metastatic lymph node ratios and the other clinico-pathological characteristics

Characteristics		Hazard ratio	95% confidence interval	P value
Sex (male vs. female)		0.731	0.469–1.138	0.166
Age (years old)		1.026	1.006–1.045	0.009
Tumor number		1.299	0.706–2.391	0.401
Location of tumor
	Middle/Upper	2.612	0.601–11.361	0.200
	Lower/Upper	1.605	0.362–7.117	0.534
Maximum tumor diameter (cm)
	2–4/≤ 2	3.841	1.317–11.208	0.014
	> 4/≤ 2	4.546	1.572–13.143	0.005
pT category
	pT2/pT1	1.025	0.376–2.795	0.961
	pT3/pT1	2.687	0.979–7.325	0.055
	pT4/pT1	1.157	0.192–6.982	0.874
Histological type
	G2/G1	2.163	1.086–4.308	0.028
	G3/G1	2.313	1.285–4.136	0.005
Histological growth pattern (expanding vs. infiltrative)		0.923	0.579–1.470	0.736
lymphatic vessel infiltrate (present vs. absent)		0.814	0.504–1.316	0.401
pN category
	PN1/pN0	1.980	1.043–3.758	0.037
	pN2/pN0	2.987	1.138–7.841	0.026
	pN3/pN0	4.380	1.201–15.966	0.025
Metastatic lymph nodes ratio (%)
	1–39/0	1.980	1.043–3.0785	0.037
	40–79/0	4.726	1.502–14.872	0.008
	80–100/0	11.841	2.787–50.321	0.001