Table 5.
Frame disruption placement and nonsense-mediated decay
| Type of initial frame disruption | Alignment verification | NMD or non-NMD region * | ||
| Observed [NMD : non-NMD] | Expected [NMD : non-NMD] | Significance | ||
| Frameshift | All cases | 159 : 188 | 294.9 : 52.1 | ††† |
| Cases with verifying alignments | 122 : 159 | 206.6 : 74.4 | ††† | |
| Stop codon | All cases | 43 : 30 | 42.9 : 30.1 | N.S. |
| Cases with verifying alignments | 22 : 17 | 17.5 : 21.5 | N.S. | |
| Frameshift or stop codon | All cases | 201 : 218 | 344.5 : 74.5 | ††† |
| Cases with verifying alignments | 141 : 184 | 232.0 : 93.0 | ††† | |
| Cases with verifying alignments (without 'probable UTR features') | 87 : 122 | 111.5 : 97.5 | ††† | |
* Ratios are for numbers expected or observed in NMD regions versus non-NMD ones. Expectations and tests are performed as for Table 1.