Figure 7.
Structural superposition of the functional site benchmark and predictions onto the LeuTAa structure. The proposed substrate transport route (defined by TM1, TM3, TM6, TM8 and TM10) and the functional site predictions from each method are displayed in the same orientation as Figure 2. The six methods are: (a) phylogenetic motifs, (b) false positive expectation, (c) site conservation, (d) Rate4Site, (e) evolutionary trace, and (f) SDPpred. Coloring of the 34 functional sites is the same as Figure 2; cyan indicates predictions not matching any of the functional sites.