Table 4.
Method | Binding sites | Cytoplasmic gate | Extracellular gate |
(a.) Unique methods | |||
Phylogenetic motif | 0.68; 0.18; 0.38 | 0.00; 0.00; 0.00 | 1.00; 0.06; 0.33 |
False positive expectation | 0.63; 0.29; 0.43 | 0.00; 0.00; 0.00 | 0.60; 0.06; 0.28 |
Site conservation | 0.46; 0.19; 0.31 | 1.00; 0.09; 0.93 | 0.80; 0.07; 0.33 |
Rate4Site | 0.54; 0.28 0.39 | 0.20; 0.02; 0.10 | 0.60; 0.07; 0.28 |
ET | 0.38; 0.16; 0.26 | 0.60; 0.05; 0.27 | 0.60; 0.05; 0.27 |
SDPpred | 0.21; 0.56; 0.36 | 0.00; 0.00; 0.00 | 0.00; 0.00; 0.00 |
(b.) Hybrid methods | |||
Union (PM + FPE) | 0.88; 0.18; 0.41 | 0.00; 0.00; 0.00 | 1.00; 0.04; 0.32 |
Intersect_2 | 0.71; 0.20; 0.40 | 0.60; 0.04; 0.26 | 0.80; 0.05; 0.31 |
Intersect_3 | 0.42; 0.35; 0.38 | 0.20; 0.02; 0.10 | 0.60; 0.07; 0.28 |
Intersect_4 | 0.33; 0.36; 0.34 | 0.00; 0.00; 0.00 | 0.60; 0.14; 0.33 |
Intersect_5 | 0.13; 0.33; 0.22 | 0.00; 0.00; 0.00 | 0.60; 0.33; 0.45 |
1 Each cell of the table includes: coverage; accuracy; and overall performance of the method on each subset of the complete benchmark dataset. The three subsets are defined in Table 2.