Figure 1.

The segment of the R6K γ ori relevant to this study including: the 106 bp enhancer, the 277 bp core and the 112 bp A + T-rich region (nt –20 to +92). Seven tandem iterons to which the Rep protein (π) binds are shown as black arrowheads. The activation and inhibition of replication by monomers and dimers, respectively, of the protein are indicated by plus and minus signs. Arrows labeled ‘a’ and ‘b’ mark the positions for the primers used in this study. Coordinates shown (–106, 1 and 277) are according to Stalker et al. (23).