Skip to main content
NCBI home page
The Journal of General Physiology logoLink to The Journal of General Physiology
. 1958 Nov 20;42(2):319–327. doi: 10.1085/jgp.42.2.319

TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS

Roy P Forster 1, Fredrik Berglund 1, Barbara R Rennick 1
PMCID: PMC2194903  PMID: 13587915

Abstract

Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted independently by separate transport mechanisms. TMAO excretion is inhibited competitively by tetraethylammonium ion (TEA) and by cyanine dye No. 863—compounds previously shown to be transferred actively by an organic base-secreting mechanism of general occurrence among vertebrates. TEA does not inhibit competitively the active tubular reabsorption of TMAO in Squalus with doses which markedly depress its tubular excretion in Lophius. Glycine, which inhibits creatine reabsorption in the dog, does not interfere competitively with its secretion in Lophius.

Full Text

The Full Text of this article is available as a PDF (534.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGLUND F., FORSTER R. P. Renal tubular transport of inorganic divalent ions by the aglomerular marine teleost, Lophius americanus. J Gen Physiol. 1958 Jan 20;41(3):429–440. doi: 10.1085/jgp.41.3.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERGLUND F., LOTSPEICH W. D. Effect of various amino acids on the renal tubular reabsorption of inorganic sulfate in the dog. Am J Physiol. 1956 Jun;185(3):539–542. doi: 10.1152/ajplegacy.1956.185.3.539. [DOI] [PubMed] [Google Scholar]
  3. BEYER K. H., RUSSO H. F. Renal tubular elimination of N1-methylnicotinamide. Am J Physiol. 1950 Feb;160(2):311–320. doi: 10.1152/ajplegacy.1950.160.2.311. [DOI] [PubMed] [Google Scholar]
  4. BEYER K. H., RUSSO H. F., TILLSON E. K., MILLER A. K., VERWEY W. F., GASS S. R. 'Benemid,' p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination. Am J Physiol. 1951 Sep;166(3):625–640. doi: 10.1152/ajplegacy.1951.166.3.625. [DOI] [PubMed] [Google Scholar]
  5. FORSTER R. P. Active cellular transport of urea by frog renal tubules. Am J Physiol. 1954 Nov;179(2):372–377. doi: 10.1152/ajplegacy.1954.179.2.372. [DOI] [PubMed] [Google Scholar]
  6. FORSTER R. P., BERGLUND F. Contrasting inhibitory effects of probenecid on the renal tubular excretion of p-aminohippurate and on the active reabsorption of urea in the dogfish, Squalus acanthias. J Cell Physiol. 1957 Apr;49(2):281–285. doi: 10.1002/jcp.1030490209. [DOI] [PubMed] [Google Scholar]
  7. FORSTER R. P., BERGLUND F. Osmotic diuresis and its effect on total electrolyte distribution in plasma and urine of the aglomerular teleost, Lophius americanus. J Gen Physiol. 1956 Jan 20;39(3):349–359. doi: 10.1085/jgp.39.3.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FOULKS J., BRAZEAU P., KOELLE E. S., GILMAN A. Renal secretion of thiosulfate in the dog. Am J Physiol. 1952 Jan;168(1):77–85. doi: 10.1152/ajplegacy.1951.168.1.77. [DOI] [PubMed] [Google Scholar]
  9. KANDEL A., PETERS L., RENNICK B. R. Inhibition of the renal tubular excretion of tetraethylammonium and N'-methylnicotinamide by basic cyanine dyes. J Pharmacol Exp Ther. 1956 Oct;118(2):204–219. [PubMed] [Google Scholar]
  10. PETERS L., FENTON K. J., WOLF M. L., KANDEL A. Inhibition of the renal tubular excretion of N'-methylnicotinamide (NMN) by small doses of a basic cyanine dye. J Pharmacol Exp Ther. 1955 Feb;113(2):148–159. [PubMed] [Google Scholar]
  11. POULSEN H. Inhibition of uric acid excretion in rabbits given probenecid or salicylic acid. Acta Pharmacol Toxicol (Copenh) 1955;11(3):277–286. doi: 10.1111/j.1600-0773.1955.tb00227.x. [DOI] [PubMed] [Google Scholar]
  12. RENNICK B. R., CALHOON D. M., GANDIA H., MOE G. K. Renal tubular secretion of tetraethylammonium in the dog and the chicken. J Pharmacol Exp Ther. 1954 Mar;110(3):309–314. [PubMed] [Google Scholar]
  13. RENNICK B., FARAH A. Studies on the renal tubular transport of tetraethylammonium ion in the dog. J Pharmacol Exp Ther. 1956 Mar;116(3):287–295. [PubMed] [Google Scholar]
  14. SCHREINER G. E. Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med. 1950 May;74(1):117–120. doi: 10.3181/00379727-74-17827. [DOI] [PubMed] [Google Scholar]
  15. TAUSSKY H. H. A microcolorimetric determination of creatine in urine by the Jaffe reaction. J Biol Chem. 1954 Jun;208(2):853–861. [PubMed] [Google Scholar]

Articles from The Journal of General Physiology are provided here courtesy of The Rockefeller University Press

RESOURCES