Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1999 Jul 1;190(1):1–8. doi: 10.1084/jem.190.1.1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

S1P reverts S inhibition of TNF-α. (A) The transcriptional activation of a TNF-α reporter gene construct was determined in transient transfections. Corrected luciferase values are indicated on the y-axis, stimulation conditions on the x-axis. Cells were either left unstimulated (nst) or were pretreated with solvent, 10 μM S (S), or 10 μM S plus 10 μM S1P (S + S1P) before activation with IgE/Ag. Data represent mean ± SD of triplicate determinations. (B) Determination of S in stimulated cells (time points are given above the panels; −, nonstimulated cells) incubated either with S alone or S plus S1P as indicated at the top by thin layer chromatography. The positions of S, S1P, and degradation product (d) are indicated with arrows (right). S served as standard (Std).