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. 1999 Aug 2;190(3):375–384. doi: 10.1084/jem.190.3.375

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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T cells from the Lck-deficient mouse are defective in their response to PMA and anti-CD28. Peripheral T cells from wild-type C57BL/6, Lck heterozygotes, or Lck-deficient animals were harvested and plated at 7.5 × 10⁴ cells per well in a 96-well round-bottom plate. Cells were stimulated with antibodies to CD28 alone (l μg/ml) or anti-CD28 plus 5 ng/ml PMA. 24 h later, cells were pulsed with [³H]thymidine and harvested after 12 h of incubation. Lck^−/− A and B represent two different Lck-deficient mice. Values are the means of triplicate samples. These results are representative of two independent experiments.