TABLE 3.
Intestinal crypt lesions in neonatal CDCD pigs 31 to 69 h after inoculation with STEC or control E. coli
| Group | Inoculum bacteria | No. of pigs | Proportion of pigs witha:
|
|||||
|---|---|---|---|---|---|---|---|---|
| Irregular goblet cellsb
|
Shift of goblet cellsb
|
Crypt activationb
|
||||||
| Cecum | Colon | Cecum | Colon | Cecum | Colon | |||
| A | 86-24 | 15 | +++ | +++ | +++c | ++ | 0 | ++ |
| B | E32511/HSC/L | 5 | +++ | +++ | +++ | +++ | 0 | 0 |
| C | 3024-94 | 6 | ++ | +++ | 0 | 0 | +++ | +++ |
| D | B2F1 | 9 | +++ | +++ | 0 | +++ | +++ | 0 |
| E | B2F1 (plasmid cured) | 4 | ++ | ++ | ++ | ++ | 0 | 0 |
| F | B2F1 Stx2d2-activatable+ | 6 | +++ | +++ | +++ | +++ | 0 | 0 |
| G | B2F1 Stx2d1-activatable+ | 7 | +++ | +++ | 0 | 0 | +++ | + |
| H | 123 (control) | 8 | ++ | 0 | 0 | 0 | 0 | 0 |
a
+++, lesions in 100% of the pigs; ++, lesions in 50 to 70% of the pigs; +, lesions in <20% of the pigs; 0, no lesions in any of the pigs.
b
The three types of lesions observed in cecal and colonic crypts of STEC-infected pigs are described in the text.
c
Cecum morphological data were available for 9 of the 15 pigs in this group.