Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1999 Sep 6;190(5):741–748. doi: 10.1084/jem.190.5.741

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Mouse neutrophils lacking FPR respond to fMLF with a concentration dependence matching that of FPR2. Peritoneal leukocytes elicited by a 3-h challenge with TG (>90% neutrophils) from wild-type mice (+/+, filled symbols) and FPR knockout littermates (−/−, open symbols) were stimulated with the indicated concentration of fMLF. (A) Calcium flux. Data are derived from the peak amplitude of the calcium transient at each concentration tested, and are plotted as a fraction of the EC₁₀₀. Data are representative of more than five experiments. (B) Chemotaxis. Conditions were tested in triplicate. Each curve represents data from a single mouse of the given genotype. Data are representative of three experiments.

Mouse neutrophils lacking FPR respond to fMLF with a concentration dependence matching that of FPR2. Peritoneal leukocytes elicited by a 3-h challenge with TG (>90% neutrophils) from wild-type mice (+/+, filled symbols) and FPR knockout littermates (−/−, open symbols) were stimulated with the indicated concentration of fMLF. (A) Calcium flux. Data are derived from the peak amplitude of the calcium transient at each concentration tested, and are plotted as a fraction of the EC₁₀₀. Data are representative of more than five experiments. (B) Chemotaxis. Conditions were tested in triplicate. Each curve represents data from a single mouse of the given genotype. Data are representative of three experiments.