Figure 2.

Enumeration of Ab-producing cells in systemic and mucosal lymphoid tissues from mice treated with anti–IL-4 mAb (hatched bars) or mock Ab (black bars). Mononuclear cells isolated from SP, MLNs, and colonic LP (LPL) of TCR-α^−/− mice treated with anti–IL-4 mAb or rat IgG2b (mock Ab) were examined by isotype-specific ELISPOT. Data represent the mean ± SEM from five mice per group of three separate experiments. *Significantly different from each other (P < 0.01) by Student's t test.