Table 5.

Specificity of T Cell Lines Activated with Peptide-loaded T2 Cells

PBLs from patient	T2 cells loaded with	Test day	§Targets
			9742 LCL			INT-MEL-8		INT-MEL-9		INT-MEL-10
			—	+Melan-A/ Mart-127–35	+Tyrosin- ase366–378	−mAb	+mAb	−mAb	+mAb	−mAb	+mAb
1	—	28	2	0	3	2	1	19	17	2	1
	Melan-A/Mart-127–35	28	6	39	4	70	6	47	15	8	11
	Tyrosinase366–378	28	2	0	3	4	4	12	8	5	4
1	—	36	7	12	7	3	7	22	26	1	0
	Melan-A/Mart-127–35	36	4	80	6	55	6	51	3	1	0
	Tyrosinase366–378	36	9	9	12	2	5	5	3	1	0
2	—	28	2	1	3	10	7	10	11	7	5
	Melan-A/Mart-127–35	28	6	17	8	69	33	57	19	13	10
	Tyrosinase366–378	28	2	2	6	45	34	30	15	13	16
2	—	36	9	12	10	9	11	48	41	6	5
	Melan-A/Mart-127–35	36	29	95	24	81	47	86	23	13	17
	Tyrosinase366–378	36	12	17	78	55	17	82	17	8	8
3	—	28	3	2	3	18	9	14	16	7	11
	Melan-A/Mart-127–35	28	14	16	15	28	12	36	25	15	16
	Tyrosinase366–378	28	0	0	1	10	2	9	3	2	1
3	—	36	5	1	2	9	12	48	49	8	16
	Melan-A/Mart-127–35	36	10	6	8	36	21	88	68	15	14
	Tyrosinase366–378	36	3	0	0	6	11	28	30	2	2
3	Melan-A/Mart-127–35	49	2	55	5	80	15	79	50	ND	ND
4	—	28	0	0	0	2	1	0	2	0	0
	Melan-A/Mart-127–35	28	0	0	0	34	36	17	29	26	31
	Tyrosinase366–378	28	4	2	7	28	19	28	23	25	17
4	—	36	3	3	2	2	4	8	9	0	0
	Melan-A/Mart-127–35	36	4	7	3	42	44	52	60	38	38
	Tyrosinase366–378	36	3	1	2	24	21	38	31	12	13
5	—	28	1	0	2	4	3	37	46	5	7
	Melan-A/Mart-127–35	28	2	0	2	11	3	28	35	2	6
	Tyrosinase366–378	28	16	13	22	75	73	31	44	12	15
5	—	36	3	2	1	7	8	52	67	0	1
	Melan-A/Mart-127–35	36	1	1	0	2	4	47	56	0	0
	Tyrosinase366–378	36	61	46	49	66	71	60	60	18	26