Table 7.

Melan-A/Mart-1_27–35–specific CTLs Can Be Isolated from Metastatic Lesions of Patients with High Frequency of CTLp to the Same Antigen

Patient	*T cells isolated from	‡Lesion number	Classification of infiltrating T cells	§T cells cocultured with	∥Lysis of
					9742 LCL loaded with			INT-MEL-8		INT-MEL-9		INT-MEL-10
					—	P1	P2	−mAb	+mAb	−mAb	+mAb	−mAb	+mAb
1	s.c. met.	3	nonbrisk	Empty T2	25¶	24	28	49	50	49	37	23	28
				T2 loaded with
				Melan-A/Mart-127–35	8	75	7	65	6	70	5	2	0
2	LN met.	9	nonbrisk	Empty T2	58	66	53	76	71	82	61	44	54
				T2 loaded with
				Melan-A/Mart-127–35	15	93	13	82	39	100	15	11	18
3	LN met.	16	absent	Empty T2	54	72	59	81	83	62	57	44	64
				T2 loaded with
				Melan-A/Mart-127–35	41	59	44	79	84	60	51	43	63