Table 1.

EAE in Mice Lacking B7 Costimulators or CD28 Induced by Active Immunization

	Clinical EAE			Histological EAE
	Incidence	Day of onset	Mean maximal score	Incidence	Meningeal foci	Parenchymal foci	Total foci
		mean ± SE	mean ± SE		mean ± SE	mean ± SE	mean ± SE
Wild-type	27/29	15.8 ± 0.9	3.0 ± 0.2	18/21	21.7 ± 7.0	15.7 ± 5.0	37.4 ± 11.9
	(93.1%)			(85.7%)
B7-1−/−	31/34	14.6 ± 0.5	2.9 ± 0.1	21/23	14.2 ± 3.4	13.0 ± 3.2	27.2 ± 6.4
	(91.2%)			(91.3%)
B7-2−/−	21/22	13.9 ± 1.0	2.4 ± 0.2	21/21	29.1 ± 5.4	9.4 ± 2.0	38.9 ± 7.0
	(95.5%)			(100.0%)
B7-1/B7-2−/−	0/18	NA	NA	7/14	12.8 ± 7.3	0.6 ± 0.4	13.3 ± 7.4
	(0.0%)			(50.0%)		P < 0.001	P < 0.03
	P < 0.0001			P = 0.05
CD28−/−	2/13	17.5 ± 1.4	2.0 ± 0.0	6/11	2.9 ± 1.3	1.5 ± 0.6	4.4 ± 1.8
	(15.4%)			(54.5%)	P < 0.01	P < 0.01	P < 0.01
	P < 0.0001