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. 1999 Sep 6;190(5):717–724. doi: 10.1084/jem.190.5.717

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Substrate specificity for Mramp. (A) Abolition of ⁶⁵Zn²⁺ uptake by Mn²⁺ in Mramp RNA–injected oocytes. Increase in uptake compared with control oocytes in the absence and presence of Mn²⁺ (10 mM as MnCl₂; P = 0.01). (B) Uptake of ⁵⁵Fe²⁺ by Mramp RNA–injected oocytes compared with water-injected controls (P < 0.001). (C) Influence of divalent cation competitors on ⁵⁵Fe²⁺ (100 μM) uptake by Mramp RNA–injected oocytes. Data from one experiment. Displayed are mean values (± SE) of uptakes (10 oocytes per experimental condition).