Table 2.

Development of Disease Correlates with a Significant Increase in the Total Number of Leukocytes and CD4⁺ Cells Recovered from the LP

Phenotype of CD4+ T cells used for reconstitution	mAb treatment	Total no. of LP leukocytes	Total no. of CD4+ cells
		×103 ± SEM	×10 3 ± SEM
4 × 105 WT CD45RBhigh	–	136.0 ± 34.9	92.7 ± 10.2
2 × 105 IL-10−/− CD45RBlow	–	64.4 ± 29.7	43.9 ± 22.8
4 × 105 WT CD45RBhigh
+ 2 × 105 WT CD45RBlow	anti–IL-10R	176.3 ± 104.5	133.3 ± 88.6
4 × 105 WT CD45RBhigh	Isotype
+ 2 × 105 CD45RBlow	control	7.9 ± 0.9	5.4 ± 0.5

RAG-2^−/− or C.B-17 SCID recipients were reconstituted with cell subsets as indicated. 8–12 wk after cell reconstitution, cells from LP were isolated. Data represent the number ± SEM of two to five animals per group from two independent experiments.