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. 1999 Oct 18;190(8):1059–1068. doi: 10.1084/jem.190.8.1059

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Most T cell tumors in MoMuLV-infected Rag2-deficient mice bypass the Rag2-mediated differentiation arrest. Typical examples of FACS™ analysis of MoMuLV-induced T cell lymphomas in Rag2-deficient mice are shown. In Rag-deficient mice, differentiation of thymocytes is arrested at the CD4⁻8⁻24⁺25⁺44^low DN stage of α/β T cell development. Whereas tumors 125 and 126 are representative examples for DN tumors, most lymphomas bypass this differentiation arrest and develop into DP or combined DN/DP immature T cell lymphomas. For example, tumor 49 represents a “transitional tumor” from the ISP to DP stage, tumor 108 is a DN/DP tumor, tumors 103 and 118 are DP, and tumors 130 and 136 are “differentiating tumors” from DN to ISP to DP. The tumors with a mixed phenotype, like 49, 130, and 136, are clonal, as the genomes of sorted fractions carry identical proviral insertions (data not shown).

Most T cell tumors in MoMuLV-infected Rag2-deficient mice bypass the Rag2-mediated differentiation arrest. Typical examples of FACS™ analysis of MoMuLV-induced T cell lymphomas in Rag2-deficient mice are shown. In Rag-deficient mice, differentiation of thymocytes is arrested at the CD4⁻8⁻24⁺25⁺44^low DN stage of α/β T cell development. Whereas tumors 125 and 126 are representative examples for DN tumors, most lymphomas bypass this differentiation arrest and develop into DP or combined DN/DP immature T cell lymphomas. For example, tumor 49 represents a “transitional tumor” from the ISP to DP stage, tumor 108 is a DN/DP tumor, tumors 103 and 118 are DP, and tumors 130 and 136 are “differentiating tumors” from DN to ISP to DP. The tumors with a mixed phenotype, like 49, 130, and 136, are clonal, as the genomes of sorted fractions carry identical proviral insertions (data not shown).