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. 1999 Oct 18;190(8):1059–1068. doi: 10.1084/jem.190.8.1059

Figure 3.

Figure 3

Tumor differentiation of MoMuLV-induced Rag-deficient tumors correlates with proviral insertion into the Pim1 locus. 76 selected tumors were classified according to the expression of CD4 and CD8 markers into CD48 (DN), CD48+24+ or CD4+824+ immature single positive (ISP), and CD4+8+ (DP) tumors, as well as tumors with a mixed phenotype, being either ISP and (+) DP or DN and (+) DP. Proviral insertions into the Pim1 and Pim2 loci of these tumors are given as percentages. 27% (15/56) of the tumors that expressed CD4 and/or CD8 (i.e., differentiated tumors) harbor a proviral insertion near Pim1, as compared with only 10% (2/20) in DN (undifferentiated) tumors. In the DP tumors, 50% (9/18) carry an insertion near Pim1. No proviral integrations in the Pim2 locus were found in the 76 tumors analyzed from Rag-deficient mice.