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. 1999 Oct 18;190(8):1135–1146. doi: 10.1084/jem.190.8.1135

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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A20 protects rat islets against cytokine-induced apoptosis. Noninfected (NI), rAd.β-gal–, and rAd.A20-infected islets were cultured in the presence or absence of IL-1β (10 U/ml) and IFN-γ (300 U/ml) for 40 h, and the percentage of apoptotic cells was determined by flow cytometry. The percentage of apoptosis in each treatment (given in upper right corner) was calculated by analysis of the percentage of events in the subdiploid region (termed A°; where DNA content <2 N) from the FL-2 area histogram (total of 10,000 events collected). The data presented are representative of four independent experiments conducted. Results demonstrate that expression of A20 in islets protects them from cytokine-mediated apoptosis.