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. 1999 Oct 18;190(8):1123–1134. doi: 10.1084/jem.190.8.1123

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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CXCR5 expression and chemotactic response profile of DN T cells from MRL-lpr mice. (A) CXCR5 expression on DN (Thy1⁺B220⁺) and conventional (Thy1⁺B220⁻) T cells. DN T cells stained with the secondary antibody alone (no 1° Ab) are shown as a control. (B and C) Chemotaxis of a 3:1 mixture of MRL-lpr and B6 splenocytes in response to (B) BLC and (C) a panel of lymphoid chemokines. Results are expressed as percentage of input cells transmigrated for DN T cells (•) and conventional T cells (○). Chemokine concentrations in C: BLC, ELC, and SLC, 1 μg/ml; SDF1, 0.3 μg/ml. MRL-lpr mice were old 5 mo at the time of analysis. Lines (B) and bars (C) represent means of duplicate transwells. Results in A are representative of three, and in B and C of two independent experiments.