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. 1999 Nov 1;190(9):1197–1200. doi: 10.1084/jem.190.9.1197

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Model for the role of NKT cells in the induction of immune deviation after inoculation of antigen into the eye. Antigen injected into the eye is captured by eye APCs that carry the antigen to the spleen. These eye APCs activate NKT cells which, in turn, produce cytokines such as TGF-β that induce the generation and expansion of antigen-specific MHC class I–restricted CD8⁺ Tr cells. These CD8⁺ Tr cells, by production of cytokines such as TGF-β and IL-10, can downregulate subsequent Th1-mediated DTH reactions against the same antigen. Note that presentation of antigen to CD8⁺ Tr cells in this system follows the exogenous pathway of MHC class I–restricted antigen presentation, which is poorly understood.