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. 1999 Nov 1;190(9):1297–1308. doi: 10.1084/jem.190.9.1297

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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IL-2–dependent, enhancer-like activities of the far-upstream (A) and upstream (B) regulatory DNA. Fragments of the human perforin gene locus identified in Fig. 3 were cloned upstream of an SV40 promoter. The data summarize four independent transient transfections of SAM-19 using 20 μg of DNA comprising an 18:1 molar excess of the experimental plasmid over the internal control vector as described in Fig. 3. The expression of the experimental reporter in the absence or presence of IL-2R signals is given after it was normalized to that derived from the control reporter to account for variations in the transfection efficiency and sample differences. These data were used to calculate the induction.