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Growth of the M. tuberculosis H37Rv and ΔnrdZ strains in B6D2/F1 mice. Mice were infected with M. tuberculosis by using an aerosol, and bacillary loads in the lungs were determined over a 14-month infection period, as described in Materials and Methods. Symbols: ▪, mice infected with the parental strain; □, mice infected with the ΔnrdZ strain. Each point represents the mean for four mice, and the error bars indicate the standard deviations.
