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Yersinia inhibits tyrosine phosphorylation of the BCR signaling complex in a YopH-dependent manner. (A) Antiphosphotyrosine blot of cell extracts from splenic B cells from anti-HEL transgenic mice. B cells were incubated with medium alone (B), wild-type (Wt), YopH− (ΔH), or pYV− (P−) Yersinia for 1 h, then activated with HEL protein (500 ng/ml) for the indicated times. (B) Blots were stripped and reprobed for actin.
