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CD2–CD48 interaction enhances T cell–APC conjugate formation. Thioglycollate-elicited macrophages were pulsed with various doses of peptide p33, mixed with INDO-1–pulsed, purified CD8+ T cells derived from TCR-transgenic control (▪) or CD2-deficient (•) mice, and centrifuged together, and conjugate formation was assessed. Data from two independent experiments were pooled, and the average and SD is shown.
