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CD2 reduces the amount of peptide required for in vivo induction of CD44 expression. TCR-transgenic control (▪) and CD2-deficient (•) mice were injected with various amounts of peptide p33, and expression of CD44 was assessed 24 h later on CD8+Vα2+ T cells. The average of two mice is shown per dose. One representative experiment of three is shown.
