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. 1999 Dec 20;190(12):1857–1868. doi: 10.1084/jem.190.12.1857

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Tissue tropism of KSHV in infected SCID-hu Thy/Liv mice. (A) Representative FACScan™ analysis for CD19 (vertical) or combined CD4⁺, CD8⁺, and CD3⁺ (horizontal) in cells pooled from three KSHV-infected implants harvested 14 d after inoculation: before T cell depletion (implant), after T cell depletion (depleted), or after sorting for CD19⁺ cells of the depleted cell population (sorted). The total number of cells in the sample is also indicated. The percentage of CD19–PE or CD4–, CD8–, CD3–FITC⁺ cells is shown in the upper left and lower right quadrants, respectively. B shows the levels of KSHV-specific latent/orf73 (filled bar) or lytic (hatched bar) transcripts in the indicated cell populations. All samples were assayed in duplicate and normalized for rRNA content. Standard deviations were too small to be visible on this scale. Levels are expressed as fold background (logarithmic scale) from uninfected CD19 cells.

Tissue tropism of KSHV in infected SCID-hu Thy/Liv mice. (A) Representative FACScan™ analysis for CD19 (vertical) or combined CD4⁺, CD8⁺, and CD3⁺ (horizontal) in cells pooled from three KSHV-infected implants harvested 14 d after inoculation: before T cell depletion (implant), after T cell depletion (depleted), or after sorting for CD19⁺ cells of the depleted cell population (sorted). The total number of cells in the sample is also indicated. The percentage of CD19–PE or CD4–, CD8–, CD3–FITC⁺ cells is shown in the upper left and lower right quadrants, respectively. B shows the levels of KSHV-specific latent/orf73 (filled bar) or lytic (hatched bar) transcripts in the indicated cell populations. All samples were assayed in duplicate and normalized for rRNA content. Standard deviations were too small to be visible on this scale. Levels are expressed as fold background (logarithmic scale) from uninfected CD19 cells.