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. 1999 Dec 20;190(12):1879–1890. doi: 10.1084/jem.190.12.1879

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Selective downstream caspase processing in activated lymphocytes. (A) Caspase-6 and -7 are also processed after TCR triggering. PBMCs were stimulated (+) or not (−) with anti-CD3 antibody and IL-2 for 1–4 d, and total proteins from 10⁶ cells were separated by SDS-PAGE and analyzed by Western blot using anti–caspase-6 or -7 antisera. The proenzymes and cleaved subunits are indicated on the right by arrows. (B) All caspases are not processed in activated cells. Day 4 unstimulated (−) or anti-CD3/IL-2 stimulated (+) PBMCs were analyzed for caspase-1, -2, or -4 processing by Western blot, as in A.

Selective downstream caspase processing in activated lymphocytes. (A) Caspase-6 and -7 are also processed after TCR triggering. PBMCs were stimulated (+) or not (−) with anti-CD3 antibody and IL-2 for 1–4 d, and total proteins from 10⁶ cells were separated by SDS-PAGE and analyzed by Western blot using anti–caspase-6 or -7 antisera. The proenzymes and cleaved subunits are indicated on the right by arrows. (B) All caspases are not processed in activated cells. Day 4 unstimulated (−) or anti-CD3/IL-2 stimulated (+) PBMCs were analyzed for caspase-1, -2, or -4 processing by Western blot, as in A.